Polkadot and Ethereum 2.0 are both sharded blockchain protocols. As such, they provide scalability by executing transactions in separate shards and provide a protocol to send messages between shards.
The shards in Ethereum 2.0 all have the same state transition function (STF), as in the rules governing how the blockchain can change state with each block. This STF provides an interface for smart contract execution. Contracts exist on a single shard and can send asynchronous messages between shards.
Likewise, in Polkadot, each shard hosts core logic, the shards are executed in parallel, and Polkadot can send cross-shard asynchronous messages. However, each Polkadot shard (in Polkadot terminology, "parachain") has a unique STF. Applications can exist either within a single shard or across shards by composing logic. Polkadot uses WebAssembly (Wasm) as a "meta-protocol". A shard's STF can be abstract as long as the validators on Polkadot can execute it within a Wasm environment. Polkadot will support smart contracts through parachains. To offer some perspective, on Ethereum, smart contracts can call each other synchronously in the same shard and asynchronously between shards. On Polkadot, smart contracts will be able to call each other synchronously in the same parachain and asynchronously across parachains.
Ethereum 2.0's main chain is called the Beacon Chain. The primary load on the Beacon Chain is attestations, which are votes on the availability of shard data and Beacon Chain validity. Each shard in Ethereum 2 is simply a blockchain with the Ethereum Wasm (eWasm) interface.
Ethereum 2.0 launched phase 0 of a multi-phase rollout in December 2020, operating in parallel to the legacy Ethereum 1.0 chain:
- Phase 0 provisioned the Beacon Chain, accepting deposits from validators and implementing proof-of-stake consensus, eventually among many shards.
- Phase 1 launches 64 shards as simple chains, to test the Beacon Chain's finality. Each shard submits "crosslinks" to the Beacon Chain, which contains the information to finalize shard data.
- Phase 1.5 integrates Eth 1 as a shard to finalize the proof-of-work chain's blocks.
- Phase 2 implements the eWasm interface, phasing out proof-of-work, finally making the system usable to end-users. 
After the launch of the Beacon Chain in phase 0, the roadmap was altered to prioritize the transition of the legacy Ethereum 1.0 chain from Proof-of-Work to Ethereum 2.0's Proof-of-Stake consensus, preceding the rollout of shards on the network. 
The network will also have "side chains" to interact with chains that are not under the finality protocol of Ethereum 2.0.
Like Ethereum 2.0, Polkadot also has a main chain, called the Relay Chain, with several shards, called parachains. Parachains are not restricted to a single interface like eWasm. Instead, they can define their own logic and interface, as long as they provide their STF to the Relay Chain validators so that they can execute it.
Polkadot, now live as a Relay Chain, only plans to launch the ability to validate up to 20 shards per block, gradually scaling up to 100 shards per block. Besides parachains, which are scheduled for execution every block, Polkadot also has parathreads, which are scheduled on a dynamic basis. This allows chains to share the sharded slots, much like multiple small airlines might share a gate at an airport.
In order to interact with chains that want to use their own finalization process (e.g. Bitcoin), Polkadot has bridge parachains that offer two-way compatibility.
Both Ethereum 2.0 and Polkadot use hybrid consensus models where block production and finality each have their own protocol. The finality protocols - Casper FFG for Ethereum 2.0 and GRANDPA for Polkadot - are both GHOST-based and can both finalize batches of blocks in one round. For block production, both protocols use slot-based protocols that randomly assign validators to a slot and provide a fork choice rule for unfinalized blocks - RandDAO/LMD for Ethereum 2.0 and BABE for Polkadot.
There are two main differences between Ethereum 2.0 and Polkadot consensus:
- Ethereum 2.0 finalizes batches of blocks according to periods of time called "epochs". The current plan is to have 32 blocks per epoch, and finalize them all in one round. With a predicted block time of 12 seconds, this means the expected time to finality is 6 minutes (12 minutes maximum).  Polkadot's finality protocol, GRANDPA, finalizes batches of blocks based on availability and validity checks that happen as the proposed chain grows. The time to finality varies with the number of checks that need to be performed (and invalidity reports cause the protocol to require extra checks). The expected time to finality is 12-60 seconds.
- Ethereum 2.0 requires a large number of validators per shard to provide strong validity guarantees. Polkadot can provide stronger guarantees with fewer validators per shard. Polkadot achieves this by making validators distribute an erasure coding to all validators in the system, such that anyone - not only the shard's validators - can reconstruct a parachain's block and test its validity. The random parachain-validator assignments and secondary checks performed by randomly selected validators make it impossible for the small set of validators on each parachain to collude.
Ethereum 2.0 is a proof-of-stake network that requires 32 ETH to stake for each validator instance.
Validators run a primary Beacon Chain node and multiple validator clients - one for each 32 ETH.
These validators get assigned to "committees", which are randomly selected groups to validate shards
in the network. Ethereum 2.0 relies on having a large validator set to provide availability and
validity guarantees: They need at least 111 validators per shard to run the network and 256
validators per shard to finalize all shards within one epoch. With 64 shards, that's 16_384
validators (given 256 validators per shard).
Polkadot can provide strong finality and availability guarantees with much fewer validators. Polkadot uses Nominated Proof of Stake (NPoS) to select validators from a smaller set, letting smaller holders nominate validators to run infrastructure while still claiming the rewards of the system, without running a node of their own. Polkadot plans to have 1_000 validators by the end of its first year of operation, and needs about ten validators for each parachain in the network.
Every shard in Ethereum 2.0 has the same STF. Each shard will submit "crosslinks" to the beacon chain and implement an eWasm execution environment. EWasm is a restricted subset of Wasm for contracts in Ethereum. The eWasm interface provides a set of methods available to contracts. There should be a similar set of development tools like Truffle and Ganache to develop for eWasm. 
Every shard in Polkadot has an abstract STF based on Wasm. Each shard can expose a custom interface, as long as the logic compiles to Wasm and the shard provides an "execute block" function to Polkadot validators. Polkadot has the Substrate development framework that allows full spectrum composability with a suite of modules that can be configured, composed, and extended to develop a chain's STF.
Shards in Ethereum 2.0 will have access to each other's state via their crosslinks and state proofs. In the model of Ethereum 2.0 with 64 shards, each one posts a crosslink in the Beacon Chain for every block,  meaning that shards could contain logic that executes based on some light client proof of a transaction on another shard.  Ethereum 2.0 has not released a specification for which nodes pass messages between shards.
Polkadot uses Cross-Consensus Message Passing Format (XCM) for parachains to send arbitrary messages to each other. Parachains open connections with each other and can send messages via their established channels. Given that collators will need to be full nodes of the Relay Chain as well, they will be connected and will be able to relay messages from parachain A to parachain B.. Messages do not pass through the Relay Chain, only proofs of post and channel operations (open, close, etc.) go into the Relay Chain. This enhances scalability by keeping data on the edges of the system.
Polkadot will add a protocol called SPREE that provides shared logic for cross-chain messages. Messages sent with SPREE carry additional guarantees about provenance and interpretation by the receiving chain.
Ethereum 2.0 governance is still unresolved. Ethereum currently uses off-chain governance procedures like GitHub discussions, All Core Devs calls, and Ethereum Magicians to make decisions about the protocol. 
Polkadot uses on-chain governance with a multicameral system. There are several avenues to issue proposals, e.g. from the on-chain Council, the Technical Committee, or from the public. All proposals ultimately pass through a public referendum, where the majority of tokens can always control the outcome. For low-turnout referenda, Polkadot uses adaptive quorum biasing to set the passing threshold. Referenda can cover a variety of topics, including fund allocation from an on-chain Treasury or modifying the underlying runtime code of the chain. Decisions get enacted on-chain and are binding and autonomous.
Upgrades on Ethereum 2.0 will follow the normal hard-fork procedure, requiring validators to upgrade their nodes to implement protocol changes.
Using the Wasm meta-protocol, Polkadot can enact chain upgrades and successful proposals without a hard fork. Anything that is within the STF, the transaction queue, or off-chain workers can be upgraded without forking the chain.
Ethereum 2.0 and Polkadot both use a sharded model where shard chains ("shards" in Ethereum 2.0 and "parachains/parathreads" in Polkadot) are secured by a main chain by linking shard state in the blocks of the main chains. The two protocols differ in a few main areas. First, all shards in Ethereum 2.0 has the same STF, while Polkadot lets shards have an abstract STF. Second, governance processes in Ethereum 2.0 are planned to be off-chain and thus require coordination for a hard fork to enact governance decisions, while in Polkadot the decisions are on-chain and enacted autonomously. Third, the validator selection mechanisms are different because Polkadot can provide strong availability and validity guarantees with a smaller number of validators per shard.